The treatment of Pseudomonas aeruginosa

Pseudomonas aeruginosa

Pseudomonas aeruginosa is a Bacterium which is encapsulated, rod-shaped, and Gram-negative. It causes diseases in animals and plants and also affects humans. It belongs to the Proteobacteria phylum, Gammaproteabacteria class, and Pseudomonadaceae family. Its higher classification is Pseudomonas. Pseudomonas aeruginosa is a type species in its group. It is a free-living bacterium commonly found in soil and water. It is Gram negative iod measuring 0.5 to 0.8 Um by 3.0 Um. All strains are almost motile and have a single polar flagellum. Its appearance is pearlescent with a grape-like, and tortilla-like has a single circular chromosome. It has a relatively large genome, which makes it encode a large number of enzymes used for various metabolic pathways. About 8% of that genome encodes the regulatory cells that enable the bacterium to adapt to complex growth environments. The type of microscope used to scan this bacterium is the electronic microscope.

Virulence of this bacterium depends on extracellular cell-associated factors. Pseudomonas aeruginosa bacterium plays a potential role in virulence factors in UTIs. The first factor is LasA, which is characterized by reduced elastolytic activity. It plays the role of breaking down host tissues, which could then facilitate the invasion of amino acid metabolism. LasB, which is necessary for activation of LasA aids in Biofilm formation and immunodulation. It also helps in breaking down host tissues and elastin. Phospholipase A releases fatty acids while phospholipase C releases phosphatesters, which are commonly found in UTI isolates. They could generate ROS. The bacterium also produces toxins like Exoenzyme. Exotocin A is responsible for tissue necrosis, while phospholipase C is thermolabile haemolysin. Exoenzyme S plays a pathogenic role disruption of immunoglobulin A and G. it also leads to depolymerization of actin filaments and contributes to resistance of macrophages. The bacterium produces proteases that cause tissue necrosis and bleeding.

Don't use plagiarized sources. Get Your Custom Essay on
The treatment of Pseudomonas aeruginosa
Just from $9/Page
Order Essay

Pseudomonas aeruginosa infections are mostly treated with antibiotics. However, in other cases, such as for people who are exposed to healthcare settings might develop resistance. This makes the infections more challenging to treat.Pseudomonas aeruginosa causes nosocomial infections. It causes bacteremia, which is an infection of the blood and most of the severe infections caused by this bacterium. It causes folliculitis when it affects the skin. It also causes urinary tract infections and pneumonia, which are infections of the lungs. The bacterium affects the soft tissue, urinary, central nervous, and gastrointestinal systems. It also affects the bones and joints, skin, ears, eye, blood, and heart. Infection of Pseudomonas aeruginosa occurs when someone is exposed to conditions that favor the virus(Sokatch, 2012).

The use of infected contact lenses

An example is when a person uses infected contact lenses while they are healthy, they might get infected. If an infection caused by this bacterium is left untreated, the condition can be life-threatening. The infections can bring about pneumonia and UTIs. However, people with a healthy system are not severely affected by this infection, unlike unhealthy people. The bacterium causes chronic infections in bronchiectasis and OCPD. The bacterium is an opportunistic pathogen and can be found in the skin of some healthy people. It has been isolated from the stool and throat of non-hospitalized patients. A 35-year-old patient who had a two-day history of shortness of breath and chest tightness was admitted to ICU since he had worsening dyspnea.

The patient was previously healthy with no history of the contagious disease, but two days later, he started experiencing coughs and sore throat. Six hours before he was admitted, he developed dyspnea, chest tightness, difficulty lying down. After physical examinations, the results were 150 bpm, T 38.9C, SpO2 99%, BP 136/91 mmHg. Nebulized bronchodilators were administered without any improvement, and he was transferred to the emergency unit, where he presented chest retractions, ABG, and undetectable blood pressure. He was admitted to ICU after developing bloody sputum, laryngeal edema, and a congested airway. Results from the lab revealed normal head CT, patchy shadows in the right inferior and superior lobes. He also developed resistance to carbapenems According to how the patient’s condition progressed quickly. In a short span of days, the pathogen could have been present since there was also resistance to antibiotics.

Presently, there is no available vaccine for this bacterium caused by infections.  However, some vaccines are undergoing clinical evaluation. Potential targets will be developed in the future. Since the bacterium is mostly spread in hospital settings, specific precautions against infections should be followed to prevent spreading. Some of them include wearing gloves and gowns when entering rooms with infected patients, hand hygiene, following proper cleaning procedures. Cleaning and disinfection should be carried out with diversified disinfectants(Frank, 2012).

Pseudomonas aeruginosa may become MDR (multidrug-resistant). Tabobactum is one of the antibiotics that is used against MDR strains. It has proven to have the ability to potent vitro activity against most of the Pseudomonas aeruginosa strains. This includes ESBL but not strains producing carbapenemase. Clinical use has also been proposed to the usage of ceftolozane-tazobactum for treating complicated urinary tract infections and intra-abdominal infections(Alan R. Hauser, 2012). In a healthcare system, those who have low immunity and are unhealthy are likely to get infected by the Pseudonomas aeruginosa bacterium. It also affects old people since their health is not stable, and they are not immune to a lot of infections. As much as there are many Pseudomonas aeruginosa, only specific produce human diseases. These are glanders, andmelioidosis.

Pseudomonas aeruginosa infections can be treated with combinations of antipseudomonal beta-lactam and aminoglycoside. Carbapenems and antipseudomonal quinolones are used together with aminoglycoside.  This is with exception to cases with patients who are febrile and have neutropenia. In such cases, monotherapy with ceftazidime or even carbapenem is administered. Two drug regimen is always recommended for these infections. The mechanism of action of this bacterium is restricted outer membrane permeability. Efflux systems pump the antibiotics out of the cells and produce enzymes that inactivate enzymes. Two factors make specific combinations of antibiotics efficient. Synergism between the combined drugs makes the two drugs enhance each other’s effects. This increases the rate of population extinction of the virus leading to a clearance rate. Collateral sensitivity is an evolved trade-off. When the evolution of resistance to a specific drug increases, there is also an increase in susceptibility to another drug (Barbosa C, 2018). This limits the ability of the bacteria to adapt to an antibiotic pair. Therefore, drug combinations chosen should lead to evolved collateral sensitivity and interaction synergistically.


Alan R. Hauser, J. R. (2012). Severe Infections caused by Pseudomonas Aeruginosa.

Barbosa C, B. R. (2018). Antibiotic combination efficacy.

Frank, D. W. (2012). Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen.

Sokatch, J. (2012). The Biology of Pseudomonas.



































































































Get Professional Assignment Help Cheaply

Buy Custom Essay

Are you busy and do not have time to handle your assignment? Are you scared that your paper will not make the grade? Do you have responsibilities that may hinder you from turning in your assignment on time? Are you tired and can barely handle your assignment? Are your grades inconsistent?

Whichever your reason is, it is valid! You can get professional academic help from our service at affordable rates. We have a team of professional academic writers who can handle all your assignments.

Why Choose Our Academic Writing Service?

  • Plagiarism free papers
  • Timely delivery
  • Any deadline
  • Skilled, Experienced Native English Writers
  • Subject-relevant academic writer
  • Adherence to paper instructions
  • Ability to tackle bulk assignments
  • Reasonable prices
  • 24/7 Customer Support
  • Get superb grades consistently

Online Academic Help With Different Subjects


Students barely have time to read. We got you! Have your literature essay or book review written without having the hassle of reading the book. You can get your literature paper custom-written for you by our literature specialists.


Do you struggle with finance? No need to torture yourself if finance is not your cup of tea. You can order your finance paper from our academic writing service and get 100% original work from competent finance experts.

Computer science

Computer science is a tough subject. Fortunately, our computer science experts are up to the match. No need to stress and have sleepless nights. Our academic writers will tackle all your computer science assignments and deliver them on time. Let us handle all your python, java, ruby, JavaScript, php , C+ assignments!


While psychology may be an interesting subject, you may lack sufficient time to handle your assignments. Don’t despair; by using our academic writing service, you can be assured of perfect grades. Moreover, your grades will be consistent.


Engineering is quite a demanding subject. Students face a lot of pressure and barely have enough time to do what they love to do. Our academic writing service got you covered! Our engineering specialists follow the paper instructions and ensure timely delivery of the paper.


In the nursing course, you may have difficulties with literature reviews, annotated bibliographies, critical essays, and other assignments. Our nursing assignment writers will offer you professional nursing paper help at low prices.


Truth be told, sociology papers can be quite exhausting. Our academic writing service relieves you of fatigue, pressure, and stress. You can relax and have peace of mind as our academic writers handle your sociology assignment.


We take pride in having some of the best business writers in the industry. Our business writers have a lot of experience in the field. They are reliable, and you can be assured of a high-grade paper. They are able to handle business papers of any subject, length, deadline, and difficulty!


We boast of having some of the most experienced statistics experts in the industry. Our statistics experts have diverse skills, expertise, and knowledge to handle any kind of assignment. They have access to all kinds of software to get your assignment done.


Writing a law essay may prove to be an insurmountable obstacle, especially when you need to know the peculiarities of the legislative framework. Take advantage of our top-notch law specialists and get superb grades and 100% satisfaction.

What discipline/subjects do you deal in?

We have highlighted some of the most popular subjects we handle above. Those are just a tip of the iceberg. We deal in all academic disciplines since our writers are as diverse. They have been drawn from across all disciplines, and orders are assigned to those writers believed to be the best in the field. In a nutshell, there is no task we cannot handle; all you need to do is place your order with us. As long as your instructions are clear, just trust we shall deliver irrespective of the discipline.

Are your writers competent enough to handle my paper?

Our essay writers are graduates with bachelor's, masters, Ph.D., and doctorate degrees in various subjects. The minimum requirement to be an essay writer with our essay writing service is to have a college degree. All our academic writers have a minimum of two years of academic writing. We have a stringent recruitment process to ensure that we get only the most competent essay writers in the industry. We also ensure that the writers are handsomely compensated for their value. The majority of our writers are native English speakers. As such, the fluency of language and grammar is impeccable.

What if I don’t like the paper?

There is a very low likelihood that you won’t like the paper.

Reasons being:

  • When assigning your order, we match the paper’s discipline with the writer’s field/specialization. Since all our writers are graduates, we match the paper’s subject with the field the writer studied. For instance, if it’s a nursing paper, only a nursing graduate and writer will handle it. Furthermore, all our writers have academic writing experience and top-notch research skills.
  • We have a quality assurance that reviews the paper before it gets to you. As such, we ensure that you get a paper that meets the required standard and will most definitely make the grade.

In the event that you don’t like your paper:

  • The writer will revise the paper up to your pleasing. You have unlimited revisions. You simply need to highlight what specifically you don’t like about the paper, and the writer will make the amendments. The paper will be revised until you are satisfied. Revisions are free of charge
  • We will have a different writer write the paper from scratch.
  • Last resort, if the above does not work, we will refund your money.

Will the professor find out I didn’t write the paper myself?

Not at all. All papers are written from scratch. There is no way your tutor or instructor will realize that you did not write the paper yourself. In fact, we recommend using our assignment help services for consistent results.

What if the paper is plagiarized?

We check all papers for plagiarism before we submit them. We use powerful plagiarism checking software such as SafeAssign, LopesWrite, and Turnitin. We also upload the plagiarism report so that you can review it. We understand that plagiarism is academic suicide. We would not take the risk of submitting plagiarized work and jeopardize your academic journey. Furthermore, we do not sell or use prewritten papers, and each paper is written from scratch.

When will I get my paper?

You determine when you get the paper by setting the deadline when placing the order. All papers are delivered within the deadline. We are well aware that we operate in a time-sensitive industry. As such, we have laid out strategies to ensure that the client receives the paper on time and they never miss the deadline. We understand that papers that are submitted late have some points deducted. We do not want you to miss any points due to late submission. We work on beating deadlines by huge margins in order to ensure that you have ample time to review the paper before you submit it.

Will anyone find out that I used your services?

We have a privacy and confidentiality policy that guides our work. We NEVER share any customer information with third parties. Noone will ever know that you used our assignment help services. It’s only between you and us. We are bound by our policies to protect the customer’s identity and information. All your information, such as your names, phone number, email, order information, and so on, are protected. We have robust security systems that ensure that your data is protected. Hacking our systems is close to impossible, and it has never happened.

How our Assignment  Help Service Works

1.      Place an order

You fill all the paper instructions in the order form. Make sure you include all the helpful materials so that our academic writers can deliver the perfect paper. It will also help to eliminate unnecessary revisions.

2.      Pay for the order

Proceed to pay for the paper so that it can be assigned to one of our expert academic writers. The paper subject is matched with the writer’s area of specialization.

3.      Track the progress

You communicate with the writer and know about the progress of the paper. The client can ask the writer for drafts of the paper. The client can upload extra material and include additional instructions from the lecturer. Receive a paper.

4.      Download the paper

The paper is sent to your email and uploaded to your personal account. You also get a plagiarism report attached to your paper.

smile and order essaysmile and order essay PLACE THIS ORDER OR A SIMILAR ORDER WITH US TODAY AND GET A PERFECT SCORE!!!

order custom essay paper