A Systematic Study of Amyloid Fibrils

A Systematic Study of Amyloid (Beta-Pleated Sheet) Fibrils Interactions with Formulation Components to Stabilize Protein Therapeutic Drugs in Injection Solutions

1. Amyloid-beta: structure, biology, and structure-based therapeutic development

Amyloidosis

2. Alzheimer’s amyloid fibrils: Structure and assembly
3. α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease
4. Preparation of Amyloid β-Protein for Structural and Functional Studies
5. Diagnostic and Therapeutic Potential of Amyloid-Reactive IgG Antibodies Contained in Human Sera
6. Serum amyloid A – a review
7. Amyloid-beta
8. Beta-amyloid and the amyloid hypothesis
9. The Pathogenesis, Investigation, and Management of Systemic Amyloidosis
10. Amyloidosis: Pathogenesis and New Therapeutic Options
11. Towards a Pharmacophore for Amyloid
12. Inhibition of diseases associated with amyloid formation
13. Peptide analogs and mimetic suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid-like deposits or beta-sheet rich pathological precursor thereof
14. Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions
15. Beta-sheet breaker peptide analogs that inhibit beta-pleated sheet formation in amyloid beta-peptide
16. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease
17. Supramolecular PEGylation of biopharmaceuticals
18. The Amyloid Stretch Hypothesis: Recruiting Proteins toward the Dark Side
19. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
20. Evaluating the Binding Selectivity of Transthyretin Amyloid Fibril Inhibitors in Blood Plasma
21. Inhibiting Transthyretin Conformational Changes that Lead to Amyloid Fibril Formation
22. Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements
23. New Drugs
24. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1
25. Protein & peptide formulation
26. Stabilization of protein-protein interactions in drug discovery
27. Current Perspectives on Stability of Protein Drugs Products during Formulation, Fill and Finish Operations
28. The development of novel excipients for the stabilization of proteins against aggregation
29. The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling
30. Impact of Product-Related Factors on Immunogenicity of Biotherapeutics
31. Minimal model systems for β-sheet secondary structure in proteins
32. Statistical Analysis of Terminal Extensions of Protein β-Strand Pairs
33. De novo design of a non-local β-sheet protein with high stability and accuracy
34. Molecular dynamics analyses of cross-β-spine steric zipper models: β-Sheet twisting and aggregation
35. β-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-β Aggregates
36. Design of Monomeric Water-Soluble β-Hairpin and β-Sheet Peptides
37. Structural Features of Amyloid Fibrils Formed from the Full-Length and Truncated Forms of Beta-2-Microglobulin Probed by Fluorescent Dye Thioflavin T
38. Dissecting the structural determinants for the difference in the mechanical stability of silk and amyloid beta-sheet stacks
39. Review: History of the Amyloid Fibril
40. Amyloid typing using antisera to prototype fibril proteins
41. A Histochemical Model of the Amyloid Fibril
42. Bio-nanoimaging: Protein Misfolding and Aggregation
43. Physical stability of pharmaceutical formulations: Solid-state characterization of amorphous dispersions
44. Advanced Approaches in Solid-State Analysis of Pharmaceuticals
45. Drug Substance Solid State Characterization
46. State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation
47. Amorphous solids- Pharmaceutical technology and drug stability in solids and aqueous states
48. Cryo-EM structure of a Transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis.
49. Secondary Structure in the Core of Amyloid Fibrils Formed from Human β₂m and its Truncated Variant ΔN6
50. Amyloid structures: much more than just a cross-β fold
51. Extreme amyloid polymorphism in Staphylococcus aureusvirulent PSMα peptides
52. Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers
53. Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy
54. Stability of Protein Pharmaceuticals: An Update
55. Protein cleavage strategies for improved analysis of the membrane proteome
56. Strategies for shotgun identification of integral membrane proteins by tandem mass spectrometry
57. Membrane protein and peptide sample handling for MS analysis using a structured MALDI target
58. Structures for amyloid fibrils
59. Targeting Protein Aggregation for the Treatment of Degenerative Diseases
60. Therapeutic Protein Aggregation: Mechanisms, Design, and Control
61. A Review on Therapeutic Proteins: Stability Aspects and Clinical Implications
62. Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides
63. Update on Alzheimer’s Disease Therapy and Prevention Strategies
64. Advanced protein formulations
65. Topological Aspects of the Design of Nanocarriers for Therapeutic Peptides and Proteins
66. Drugs and drug delivery systems targeting amyloid-β in Alzheimer’s disease
67. A Comprehensive Guide for Performing Sample Preparation and Top-Down Protein Analysis
68. Delivery of Therapeutic Proteins
69. Recent developments in protein and peptide parenteral delivery approaches
70. Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)
71. Protein delivery options: how well have we succeeded?
72. Highly Concentrated Protein Formulations: Finding Solutions for the Next Generation of Parenteral Biologics
73. Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery
74. Drug Delivery with Organic Solvents or Colloidal Dispersed Systems
75. Commercial challenges of protein drug delivery
76. Ocular delivery of proteins and peptides: Challenges and novel formulation approaches.
77. Therapeutic Protein
78. Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences
79. Properties and identification of human protein drug targets
80. Protein-Peptide Interactions Revolutionize Drug Development
81. Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
82. Pharmaceutical approaches related to systemic delivery of protein and peptide drugs: An overview
83. Amyloid as a Depot for the Formulation of Long-Acting Drugs
84. An Amino Acid Code for Beta Sheet Packing Structure
85. Beta Pleated Sheet Fibrils-A comparison of Native Amyloid with Synthetic Protein Fibrils
86. Determining Beta-Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy
87. The Discovery of the alpha-helix and Beta Sheet, the principal structural features of proteins
88. Exploring Beta Sheet Structure and Interactions with Chemical Model Systems
89. Protein Drug Stability: A formulation Challenge
90. Stability and Analysis of Solid State Forms in Pharmaceutical Powders
91. Structural Features of Amyloid Fibrils Formed from the Full length and Truncated Forms of Beta 2-Microglobulin Probed by Fluorescent Dye Thioflavin T
92. The Peptide hormone glucagon forms amyloid fibrils with two coexisting Beta strand conformations
93. Stability of Proteins in Aqueous Solution and Solid State
94. Protein Stability: Impact of Formulation excipients and manufacturing processes in protein-based pharmaceuticals
95. Immunogenicity of Therapeutic Protein Aggregates
96. Improvement of Protein Analysis: Improve Techniques for protein analysis focusing on membrane proteins and hydrophobic peptides
97. Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils.
98. Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly
99. Orthogonal packing of .beta.-pleated sheets in proteins
100. Quantitative evaluation of Congo red binding to amyloid-like proteins with a beta-pleated sheet confor
101. Commercial challenges of protein drug delivery

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches.

Therapeutic Protein

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

Properties and identification of human protein drug targets

Protein-Peptide Interactions Revolutionize Drug Development

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Pharmaceutical approaches related to systemic delivery of protein and peptide drugs: An overview

Amyloid as a Depot for the Formulation of Long-Acting Drugs

An Amino Acid Code for Beta Sheet Packing Structure

Beta Pleated Sheet Fibrils-A comparison of Native Amyloid with Synthetic Protein Fibrils

Determining Beta-Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy

The Discovery of the alpha-helix and Beta Sheet, the principal structural features of proteins

Exploring Beta Sheet Structure and Interactions with Chemical Model Systems

Protein Drug Stability: A formulation Challenge

Stability and Analysis of Solid State Forms in Pharmaceutical Powders

Structural Features of Amyloid Fibrils Formed from the Full length and Truncated Forms of Beta 2-Microglobulin Probed by Fluorescent Dye Thioflavin T

The Peptide hormone glucagon forms amyloid fibrils with two coexisting Beta strand conformations

Stability of Proteins in Aqueous Solution and Solid State

Protein Stability: Impact of Formulation excipients and manufacturing processes in protein-based pharmaceuticals

Immunogenicity of Therapeutic Protein Aggregates

Improvement of Protein Analysis: Improve Techniques for protein analysis focusing on membrane proteins and hydrophobic peptides

Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils.

Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly

Orthogonal packing of .beta.-pleated sheets in proteins

Quantitative evaluation of Congo red binding to amyloid-like proteins with a beta-pleated sheet conformation

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